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Recombinant Human CRTAM (His Tag)

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翌圣生物科技(上海)股份有限公司更新時(shí)間：2024-12-24 09:03:45

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詳細(xì)介紹

CRTAM (Class I-restricted T cell-associated molecule) is a nectin family member of the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. NK activation receptor engagement, but not cytokines, also induce NK CRTAM expression. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells, and a rare splenic T zone-restricted.

產(chǎn)品性質(zhì)

別名	CD355 antigen; CD355; CRTAM
Uniprot No.	O95727.1
表達(dá)區(qū)間及表達(dá)系統(tǒng)	Recombinant Human CRTAM Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Ser18-Gly287.
分子量	Approximately 31.1 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
純度	> 95% as determined by SDS-PAGE.
活性	ELISA Data: Immobilized Human CRTAM, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CRTAM Antibody, hFc Tag with the EC50 of 57.3ng/ml determined by ELISA.
內(nèi)毒素	< 1.0 EU per 1μg of the protein by the LAL method.
制劑	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
復(fù)溶	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.